A captain in the U.S. Navy, was a naval aviator and flight surgeon. He served as Mission Specialist 1 for STS-107. Brown received a bachelor of science in biology from the College of William and Mary in 1978 and a doctorate in medicine from Eastern Virginia Medical School in 1982. Brown, as a member of the Blue Team, worked with the following experiments: European Space Agency Advanced Respiratory Monitoring System (ARMS); Combustion Module (CM-2), which included the Laminar Soot Processes (LSP), Water Mist Fire Suppression (MIST) and Structures of Flame Balls at Low Lewis-number (SOFBALL) experiments; Mediterranean Israeli Dust Experiment (MEIDEX); and the Physiology and Biochemistry Team (PhAB4) suite of experiments, which included Calcium Kinetics, Latent Virus Shedding, Protein Turnover and Renal Stone Risk.
Selected by NASA in April 1996, Brown was making his first spaceflight.